The 3 ’ - 5 ’ exoribonuclease Dis 3 regulates the expression of specific microRNAs in Drosophila
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چکیده
The 3’-5’ exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs. Benjamin P. Towler, Christopher I. Jones, Sandra C. Viegas, Patricia Apura, Joseph A. Waldron, Sarah K. Smalley, Cecilia M. Arraiano and Sarah F. Newbury*. 1 Brighton and Sussex Medical School, Medical Research Building, University of Sussex, Falmer, Brighton, BN1 9PS, UK. 2 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780157 Oeiras, Portugal.
منابع مشابه
The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs
Dis3 is a highly conserved exoribonuclease which degrades RNAs in the 3'-5' direction. Mutations in Dis3 are associated with a number of human cancers including multiple myeloma and acute myeloid leukemia. In this work, we have assessed the effect of a Dis3 knockdown on Drosophila imaginal disc development and on expression of mature microRNAs. We find that Dis3 knockdown severely disrupts the ...
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تاریخ انتشار 2015